Comparative evaluation of trypanocidal activities of cissus multistriata and saba florida (benth) leaf extracts
Omale James
Departmnet of Biochemistry
Kogi state Universit
Anyigba, Nigeria
Abstract:
In this investigation, comparative evaluation of trypanocidal activities of Cissus multistriata and Saba florida (Benth) leaf extracts in the treatment of trypanosome brucei brucei -infected rats were carried out. The albino rats were treated for 7 days with 200 and 400mg/kg b.w of plant extracts intraperitoneally (ip) after establishment of parasitemia. No significant (P< 0.05) changes in body weights were observed in all the groups. Improvements of packed cell volume (PCV) as well as red blood cell count s (RBC) were observed in the rats treated with Cissus multistriata leaf extract and Berenil (standard drug). White blood cell counts (WBC) did not change significantly (P< 0.05) in the infected treated groups. The results also showed that treatment significantly increased total serum protein with Saba florida leaf extract demonstrating greater potential in a graded dose response manner. In conclusion, the hydromethanolic leaf extracts of the two plants had trypanocidal activities at different concentrations and they could be useful in the management of trypanosomiasis.
Keywords:
Cissus multistriata, Saba florida, trypanosome brucei brucei, trypanosomiasis, and albino rats.
